Preclinical assessment and randomized Phase I study of CT-P63, a broadly neutralizing antibody targeting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Article Published on 2022-12-012022-11-15 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 비임상, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome Beta Blood caused clinically Concentration coronavirus COVID-19 creatine phosphokinase CT-P63 deaths declining Delta demonstrated detectable dose double-blind evaluated groups healthy volunteer Immunity in vitro in vivo Infection Infectious virus lung monoclonal monoclonal antibody morbidity and mortality mutated variant Neutralizing Neutralizing activity neutralizing antibody neutralizing antibody. omicron pandemic parallel-group participant peaked phase Placebo placebo-controlled Preclinical prevalent Prophylactic Randomized reduced respiratory tract Safe SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants of concern Serious Adverse Events significantly single ascending dose study drug TEAE titre Tolerability Transgenic mouse treated Treatment treatment-emergent adverse event vaccination variants variants of SARS-CoV-2 wild-type [DOI] 10.1080/22221751.2022.2117094 PMC 바로가기
Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domainArticle Published on 2022-10-132022-11-15 Journal: Cell [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 ACE2 binding antibody antibody treatment artificial intelligence COVID-19 COVID-19 pandemic deep deep learning deep sequencing develop directed evolution domain Evolution of SARS-CoV-2 machine learning mutated variant Mutation mutations Neutralizing antibodies neutralizing antibody omicron predict Predictive Protein protein engineering RBD RBD variants representing SARS-CoV-2 variant Selection sequence the SARS-CoV-2 therapeutic Trajectories Vaccine variant variants viral escape viral spike protein yeast yeast display. [DOI] 10.1016/j.cell.2022.08.024 PMC 바로가기
In silico evaluation of Philippine Natural Products against SARS-CoV-2 Main ProteaseArticle Published on 2022-10-072022-11-15 Journal: Journal of molecular modeling [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] Activation acute respiratory syndrome ADME ADMET antiviral drug betweenness Betweenness centrality binding site catalytic dyad Clinical treatment complex coronavirus COVID-19 database docking experiments drugs enzyme highest in silico In silico methods in vitro in vivo inhibitor inhibitory inhibitory effect Ligand molecular docking molecular dynamics MPro mutated variant natural natural products network network analysis offer pandemic Population potential mechanism predicted product protease Protein reported residue responsible risk SARS-CoV-2 SARS-CoV-2. severe COVID-19 Spread the SARS-CoV-2 trajectory Vaccine Vaccines viral replication WHO World Health Organization [DOI] 10.1007/s00894-022-05334-1 PMC 바로가기
Heterologous immunity induced by 1st generation COVID-19 vaccines and its role in developing a pan-coronavirus vaccineArticle Published on 2022-08-152022-11-16 Journal: Frontiers in Immunology [Category] SARS, 변종, [키워드] acute respiratory syndrome adaptive addition COVID-19 COVID-19 pandemic COVID-19 vaccine cross-reactive develop Evolution Heterologous heterologous immunity highlight Hospitalization illnesses Immunity immunization individual Infection mechanism Mortality MOST mutated mutated variant other coronaviruses pan-coronavirus vaccine pandemic Prevent PROTECT protective role Protein SARS-CoV-2 SARS-CoV-2 antigens T cell the Spike understanding universal vaccine development. Vaccine Vaccine development variant viral strains virulent virus strain [DOI] 10.3389/fimmu.2022.952229 PMC 바로가기
A Short Series of Case Reports of COVID-19 in Immunocompromised Patients면역 저하 환자의 COVID-19에 대한 짧은 일련의 사례 보고서Case Reports Published on 2022-04-292022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] aa deletion Alpha variant amino-acid analyzed binding site clinical sample clinical samples co-morbidities collected coronavirus COVID-19 cultured virus Deceased Deletion deletions Effectiveness eight elicited epitope Epitopes fatal SARS fitness immune immune response immune responses Immunity Immunocompromised immunocompromised individual immunocompromised individuals Immunocompromised patients include individual Infection infection. morbidities mutated variant Mutation N-terminal domain NAb titer neutralizing antibody NTD occur omicron Omicron variant pathogen Patient patients peptide report risk SARS-CoV-2 SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2 variants Sery Surface glycoprotein survival the SARS-CoV-2 titers vaccination Vaccinations Vaccine variant viral genome viral genome analysis [DOI] 10.3390/v14050934 PMC 바로가기 [Article Type] Case Reports
SARS-CoV-2 variants with reduced infectivity and varied sensitivity to the BNT162b2 vaccine are developed during the course of infection감염성이 감소하고 BNT162B2 백신에 대한 감도가 다양한 SARS-COV-2 변이체가 감염 과정에서 개발됩니다.Clinical Trial Published on 2022-01-122022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, 변종, 임상, 치료기술, 치료법, [키워드] addition Affect Analysis analyzed Anti-spike Antibody neutralization antibody neutralization activity Author BNT162b2 BNT162b2 vaccine circulating convalescent plasma Course COVID-19 vaccine COVID-19 vaccines demonstrated elicit employment Evolution Frequency highlight Host human host human population impair in-depth analysis increase in individual infected individual infected individuals Infection infectivity capacity intra-host SARS-CoV-2 variant intra-host SARS-CoV-2 variants Intra-host variant intra-host variants L1197I mutation landscape less low frequencies mRNA mRNA-based mutated mutated variant mutated variants N gene N genes natural infection neutralization Neutralizing antibodies nose-throat swab nose-throat swabs pandemic plasma plasma neutralization activity platform Point mutation potential circulating variants Protective Quasispecies quasispecy raised reduced respiratory Respiratory system S gene S2 subunit SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 intra-host variability SARS-CoV-2 intra-host variant SARS-CoV-2 intra-host variants SARS-CoV-2 mutagenesis SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Sequencing Sequencing database Sequencing databases single-genome sequencing Spike protein Spike proteins spike variant Spread swab sample swab samples the SARS-CoV-2 the spike protein vaccinated individuals vaccination rate variant variants variants of concern [DOI] 10.1371/journal.ppat.1010242 PMC 바로가기 [Article Type] Clinical Trial
Sensitivity of two SARS-CoV-2 variants with spike protein mutations to neutralising antibodies중화 항체에 대한 스파이크 단백질 돌연변이를 갖는 2 개의 SARS-COV-2 변이체의 민감도Original Paper Published on 2021-10-042022-09-01 Journal: Virus Genes [Category] MERS, SARS, 변종, 진단, [키워드] accumulate addition Affect antibody antibody treatment assigned B.1.351 Complete COVID-19 distribution Donor Efficacy elicit escape mutation evaluated greater humoral immune response Immune escape Immunocompromised patient infected patient infected with SARS-CoV-2 insensitivity Lineage monoclonal mutated variant Mutation Mutation E484K mutations neutralisation neutralising Neutralising activity Neutralising Antibodies neutralising antibody Patient patients Prolonged infection reduction in representing SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant sensitivity serum sample serum samples Spike protein the spike protein Therapeutics Vaccine variant variants variants of concern virus virus variant wild-type wild-type SARS-CoV-2 [DOI] 10.1007/s11262-021-01871-8 PMC 바로가기 [Article Type] Original Paper
The impact of spike mutated variants of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit recombinant vaccinesSARS-CoV2[알파, 베타, 감마, 델타 및 람다]의 스파이크 돌연변이 변이체가 소단위 재조합 백신의 효능에 미치는 영향Review Published on 2021-07-012022-09-11 Journal: The Brazilian journal of infectious diseases : an [Category] SARS, 변종, 진단, [키워드] (alpha (Alpha) (Beta ACE2 Alpha alpha and delta variants Alpha variant analysis angiotensin Angiotensin-converting enzyme antibody Antigen B.1.1.7 B.1.351 B.1.617 Beta bind binding COVID-19 Delta delta variant described Efficacy elicited focus Gamma greater host cell human infection humans immune response immunization infection process Invasion Lambda mutated variant mutated variants Mutation neutralize Prevent Protein RBD receptor Receptor binding domain recombinant vaccine recombinant vaccines reported robust SARS-CoV-2 SARS-CoV-2 variants SARS-CoV2 specific antibodies specific antibody spike Spike protein subunit subunit protein vaccine Subunit vaccine subunit vaccines Vaccine Vaccine development vaccine efficacy variant Variant. variants variants of SARS-CoV-2 virus [DOI] 10.1016/j.bjid.2021.101606 PMC 바로가기 [Article Type] Review
A Summary of the SARS-CoV-2 Vaccines and Technologies Available or under DevelopmentReview Published on 2021-06-222022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] age clinical trial clinical trials country COVID-19 COVID-19 pandemic develop development DNA vaccines dosage Effect effective Factor humans immune response inactivated viruses include initiated Live attenuated vaccines Messenger RNA Modification mounted mRNA mutated variant mutated variants outcomes parameters Phase 3 Protein protocol researcher SARS-CoV-2 Seven Side effects storage conditions subunits technology the SARS-CoV-2 Vaccine vaccinee Vaccines vectors viral-like particles [DOI] 10.3390/pathogens10070788 PMC 바로가기 [Article Type] Review
Status Report on COVID-19 Vaccines DevelopmentTropical, Travel and Emerging Infections (L Chen and A Boggild, Section Editors) Published on 2021-04-142022-11-01 Journal: Current Infectious Disease Reports [Category] COVID-19, [키워드] accelerated acute respiratory syndrome affected animal model animal models Antigen approach approved Assays and standards breadth cell-mediated immune response circulating Complete Coronavirus-2 COVID-19 COVID-19 vaccine development COVID-19 vaccines Critical develop development Efficacy efficacy analysis Emergency use finding humoral immune response inactivated individuals International Intervention MOST multivalent vaccine mutated variant Mutation new SARS-CoV-2 nucleic acid pandemic Preclinical and clinical development preliminary finding profile Protein reagents recent report review SARS-CoV-2 SARS-CoV-2 variants shown spike status surface protein Vaccine Vaccines variant [DOI] 10.1007/s11908-021-00752-3 PMC 바로가기 [Article Type] Tropical, Travel and Emerging Infections (L Chen and A Boggild, Section Editors)